It only takes a pill. It just needs to be cut out. It is all about estrogen. It is all about testosterone. Disease is the typical outcome of life built into our genetic code without the means for change. Simple, isn’t it? When it comes to conventional medicine, when it comes to the traditional medicine marketing mantra, simple is the modus operandi. Simple would be nice. Simple would be … well, simple. If only simple existed. No matter how much we may want, the body does not work on simple. The perfect example of this simple modus operandi is in the relationship between hormones and cancer.

Simple would have you believe men are nothing more than testosterone-fueled erections and women are merely estrogen-fueled hot flashes. Just look at the popular medical marketing mantra: testosterone causes prostate cancer; estrogen causes breast cancer. If a man is diagnosed with prostate cancer or a woman with breast cancer, testosterone or estrogen is the culprit, and these hormones must be eliminated. It is almost modern-day Wizard of Oz fear-mongering: lions and tigers and bears, oh my!

Though our bodies may seem simple enough, they are a beautiful, complex biochemical machine maintaining an intricate, delicate, balance designed for healing potential. Thank goodness for that complexity! Though advocated as simple, the body is anything but simple.

If it is not simple, then the opposite is true: complexity rules the day. Hormones, especially about cancer, are a perfect example of this complexity. Hormones are just one piece of a very complex puzzle when it comes to hormones and cancer. For scientific, safe, and effective hormone knowledge and therapy in patients with cancer, it takes all the following:

• Re-evaluate definition of normal
• proper hormone evaluation
• knowledge of hormone levels
• hormone balance
• hormone metabolites
• hormone receptors
• outside influences
• physiologic hormone therapy

Re-evaluate normal

The first question that often comes up in the discussion of hormones is are they normal. But, what is normal after all? Who is normal? That discussion could go on for days. Normal is defined as what falls within the statistical reference range of normal. Normal is then determined as a percentage of the population as a whole. The definition of normal can change based on a shift in the population as a whole. As the population becomes more abnormal, then a shift occurs as normal is re-defined. What was once abnormal is now normal, and what is now normal is abnormal.

Statistically speaking, the top 2.5% and the bottom 2.5% are determined to be statistically abnormal, and the other 95% are deemed normal. If I used that logic with my kids, a 65 on a test at school would be considered statistically normal right? From my perspective and my child’s, 65 would not be normal. A 65 falls far closer to failing than succeeding, yet it is statistically normal. This highlights the limitations of this simple definition of normal when discussing anything, but especially hormone levels in people with cancer.

This approach may work for disease medicine (though I highly doubt it), but it is not the best for the pursuit of healing from cancer.

John R. Lee, David Zava, Virginia Hopkins]

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Proper hormone evaluation

In the past, hormone evaluation was limited to blood. Today, hormone evaluations can come in all shapes and sizes: from blood to saliva to urine. Even blood spot and urine spot hormone evaluation are available today. People like my good friend Dr. David Zava have pioneered these hormone evaluation techniques. When it comes to different methods to evaluate hormones, no method is better than another, but it is all about perspective. Each hormone evaluation is a different perspective or separate window into the room of hormone physiology. No one window is better than the other, but each provides a different window with a different perspective.

The various windows provide different clinical aspects that are helping to provide a complete evaluation of hormone physiology of the individual and to provide a complete hormone treatment regimen for the specific environment of the individual with cancer. The question becomes what perspective or what window offers the most useful information for the clinical issue at hand. Is a single image good enough, or is a panoramic view better? For me, I like the complete hormone panoramic view. In the treatment and healing of cancer, no questions should be left unanswered; or in this perspective, is viewed.

Hormone levels

What is your number? The conventional medicine marketing mantra is full of this. Just look at the Testosterone marketing for men. “What is your number?” is a standard marketing cry for low Testosterone clinics around the country. For this reason, I call testosterone clinics the 21st-century version of the methadone clinic.

Contrary to most thought today, hormones are not just about the specific numbers. Hormones are a means of communication throughout the body; a language if you will. I am always amazed at the answers I get when I ask post-menopausal women if they still make hormones. Or men older than 65, if they make testosterone. Most will say no. Because of what they are exposed to in marketing, I am not surprised by their responses. Of course, the answer to both questions is yes. The body must have these hormones to communicate, to live, and to survive. Even after menopause, women need some estrogen.

It can be about the numbers if the numbers are exceedingly low or exceedingly high. However, that is a rare finding and usually occurs as a result of hormone therapy. Hormone impacts on individuals with cancer are rarely about the levels, but more about the balance.

Hormone balance

Hormones must exist in balance. Balance is the source of health and wellness. Just look at the body for the importance of balance. The human body is created in balance: two eyes, two ears, two legs. Try losing a limb and see how the rest of your body is affected by the imbalance. Bumps, bruises, and even worse are definitely in the future. The loss of balance is often the precipitating cause of symptoms short term and contribution to disease risk in the long-term. The most well-publicized hormone imbalance is that of the estrogens and progesterone in women, but the irregularities of hormones are widespread in the body and have a significant impact on cancer risk and cancer healing. Imbalances are not just isolated to hormones, but also apply to neurotransmitters and the immune system. The body must exist in balance.

Hormone metabolism

Metabolism is presented as merely the means to gain or lose weight. Metabolism goes far beyond this simple definition. Metabolism is the mass production of day-to-day cellular processes that help the cell survive and thrive or not. In reality, metabolism is a measure of optimal cellular and thus body homeostasis. Thus metabolism can correctly be defined and applied to all cellular and body functions that result in day-to-day cellular homeostasis.

How the body processes hormones are called hormone metabolism. Hormone metabolites are just as important as the individual hormone levels and the hormone balance themselves. It may be more important as they reflect the flow, the trend of hormone movement, which is so essential in the assessment of function. We need to look at function, not static values — the body functions. The body is by no means static.

Hormone metabolites are just as they sound—the breakdown products that are the result of hormone metabolism. Whether the body endogenously makes hormones or whether they are exogenously administered through hormone therapy, hormone metabolism manages the breakdown of these hormones to help the body survive, thrive, or not.

The error is to think that hormone metabolites are merely waste products without any activity or physiologic significance. This has been the long-held thought. The truth is that hormone metabolites are very much active in hormone signaling. Hormone metabolites provide much of the risk and side effects equated to hormones and hormone therapy in cancer that is often overlooked. Not all hormone metabolites are harmful. Some of these hormone metabolites can also provide significant protection.

Jennifer K. Reilly

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Hormone receptors

Hormone receptors are just what the words imply. They are the receptors that the individual hormones bind too. Once the hormones bind to the respective receptors, the signal of the hormone is then internalized inside the cell through a series of secondary messengers. Hormone receptors are the doorway to the cell. Most of these signals then interact with DNA to turn genes off/on. There are, however, non-DNA and non-hormone receptor signaling that occurs as well. Again, straightforward need not apply. As crucial as hormone receptors are to the signal transmission of hormones to the cell, they are impossible to assess except in the case of physical tissue specimens in biopsies.

Outside influences

We are all products of our genetics (DNA) and our environment. The DNA that we have inherited from our parents is hard-wired. In contrast, the expression of DNA is not hard-wired but is quite fluid. The lifestyle choices we make and the environment we expose our DNA to influences the very expression of our DNA. Let this settle in for a moment. Though our DNA is fixed, we can determine whether genes are turned on or genes are turned off. These effects can be good, or they can be bad. This is called the study of epigenetics or the study of things “above genetics.” Above genetics includes items — i.e., diet, stress, sleep — that are above genetics, yet influence the expression of genetics. For example, studies have shown that our diet can affect our genetic expression to increase or decrease cancer risk. [1] Sorry, when your mom told you to eat your broccoli, she knew something that researchers are just now discovering. Broccoli anyone?

The same “environment” that can influence genetics can also affect the expression of hormones. One might call it the study of epihormones or “above hormones” if such a review existed. Based on the current dogma and outcomes of conventional medicine in hormones and cancer, it clearly should exist.

Physiologic hormone therapy

The classic approach to most things these days is that more is better: super-size that drink, super-size those fries. Unfortunately, the same super-size logic applies to medicine today. This is no more apparent than in hormones. Just look at how conventional medicine handles low hormones: More is good, and a lot is even better.

The conventional approach to hormones is the same approach to chemotherapy: more is better; when the ole testosterone levels in men or estrogen levels in women are running on empty, you stop off at your local doc station to filler up with more testosterone or estrogen. The overdosing of these hormones is evident in the testing of these patients as well as the complications of these dosing strategies. If testosterone therapy causes cancer or thickens the blood (polycythemia) or causes aggressiveness/rage/anger issues, then why doesn’t endogenous testosterone production cause the same at age 24 when peak testosterone production occurs in men? The point is that is doesn’t.

These symptoms are simply the result of overdosing. If testosterone doesn’t cause these symptoms at the peak age of production of 24, then it shouldn’t work with optimal physiologic dosing. It only does with overdosing. The same can be said of estrogen and breast cancer. If testosterone caused prostate cancer and if estrogen caused breast cancer, then every young man and young woman would have breast cancer. They don’t. The more is better philosophy — the super-size logic — need not apply to hormone therapy. That is if your goal is health and healing.

The post ‘More is better’ need not apply to hormone therapy appeared first on Cancer Tutor.

For years, Dr. Thomas Lodi and I have been strong advocates for the IV use of Vitamin C (IVC) in the treatment of cancer. The science on IVC is not new and, in fact, has been around for quite some time.  Linus Pauling and Ewan Cameron published their landmark study, Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer, on IV Vitamin C in cancer more than 40 years ago in 1976. In this early study, Cameron and Pauling found that IVC increased the survival time of those who received a very low dose of IVC (10 grams) in those with advanced cancer compared to those who did not.

Even though Linus Pauling won the Nobel Prize for his work on Vitamin C, it was WJ McCormick that was the first to propose the benefits of Vitamin C in the treatment of cancer even earlier in 1954. Despite the long history of the study of IV Vitamin C and cancer, the research on IV Vitamin C in the treatment of cancer continues. The use of IV Vitamin C in cancer is currently being studied at numerous sites across the United States, including the University of Iowa, Thomas Jefferson University, the University of Kansas Medical Center, and Johns Hopkins University, throughout Europe and the rest of the world.

Intravenous Vitamin C is a natural, yet extremely powerful tool to directly attack cancer and yes, kill cancer cells. In general, patients with cancer have been shown to have significantly depleted levels of Vitamin C compared to individuals without cancer — modern-day metabolic scurvy if you will. The scientific evidence for the use of IV Vitamin C as a treatment option and a treatment adjunct in cancer continues to grow.

In fact, it is my opinion that the evidence for the IV use of Vitamin C in cancer is so strong, it should be considered a mainstay in any and all treatment plans in the treatment of cancer. I would even use the mainstream medicine words standard of care in reference to IV Vitamin C in the treatment of cancer. Not standard of care as defined by mainstream medicine, what everybody is doing, but instead use the standard of care that results from the overwhelming evidence that supports its efficacy and safety. There are a lot of cancer treatments used on people every day that can’t meet the level of evidence available for IV Vitamin C.

Why not just use oral Vitamin C? This gets technical, but an important question to answer. The simple answer is pharmacokinetics. Pharmacokinetics is the study of the body’s absorption, distribution, metabolism and the excretion of drugs, which also includes vitamins/supplements. The perfect example is a very powerful antibiotic vancomycin. Oral and IV vancomycin have very different effects because of the different absorption, distribution, metabolism and excretion properties of the IV and oral delivery.

It is not that one delivery method alone is outright better than another, but that the body processes the treatment therapy, drug in this example, which dictates and effects the therapy effectiveness. Pharmacokinetics can also apply to vitamins and in this case, Vitamin C. Know this next bit of information and you will know more than most doctors and empower your healing. Oral Vitamin C is limited by 2 significant factors.

First, Vitamin C has a maximum absorption rate of approximately 200 mg/hour. Most Vitamin C supplements far exceed 1,000 mg, let alone 200 mg. If one takes more than 200 mg oral Vitamin C, the vast majority of it is flushed out of the body not used. Second, and probably most important, oral Vitamin C has a very low peak plasma concentration, likely related to the first point. Oral Vitamin C will not raise plasma concentration significantly higher than 200 microMolar. The lowest plasma concentration that has been shown to be toxic to cancer cells is 500 microMolar with the target maximum cancer kill rate in the 10-20 millimolar range (see diagram to left from the riordanclinic).

In contrast, IV Vitamin C has been shown to reach peak plasma concentrations of 20-40 millimolar and higher. That is at least a 20,000 times higher peak plasma concentration with IV Vitamin C compared to oral Vitamin C. That is the power of pharmacokinetics. Pharmacokinetics is also the reason why 2 follow up studies (published in 1975 and 1985) to Pauling’s original 1976 research found no benefit from oral Vitamin C, yet the research on IV Vitamin C that has followed has repeatedly shown benefit.

Benefits of IV Vitamin C in Cancer

The fact that a natural therapy has such significant evidence to support its use is surprising to a lot of people. In fact, when you look at the evidence with IV Vitamin C, the volume actually dwarfs much of the research that pushes many prescriptions drugs today. The published evidence for the benefit of IV Vitamin C in cancer includes:

• Improved Quality of Life
• Increased overall survival
• Reduction in pain
• Increased energy
• Increased appetite
• Decreased cancer-associated inflammation
• Prevents cancer-associated sepsis
• Combats infections (viral, bacterial, fungi)
• Reduces side effects and toxicity of chemotherapy
• Reduces side effects and toxicity of radiation
• Augments the cancer kill rate of chemotherapy
• Augments the cancer kill rate of radiation
• Kills cancer cells
• Allows a decrease in the dose of chemotherapy, yet maintains the same cancer kill rate
• Improves surgery recovery time
• Reduces post-surgery pain
• May even decrease post-surgery cancer recurrence
• Kills cancer stem cells (CSC)

All this benefit and it is non-toxic to healthy cells.

Most importantly, the IV use of Vitamin C has repeatedly been shown to be safe at therapeutic dosing as high as 300 grams daily. How does that compare to your average chemotherapy, radiation, or surgical treatment for cancer? The safety, the increased quality of life and the increased overall survival alone are reasons all people battling cancer should receive IV Vitamin C. Any therapy that is safe, improves outcome, and reduces side effects should be an absolute must!

Is IV Vitamin C helpful in all cancer types?

Intravenous Vitamin C has been shown to be effective in both solid (i.e. brain, breast, prostate) and blood-borne cancers (i.e. leukemia, multiple myeloma) including:

• Brain (Glioblastoma)
• Ovarian
• Lung (Non-small cell lung cancer)
• Leukemia
• Pancreatic
• Breast
• Prostate
• Melanoma
• Liver
• Colon
• Bladder
• Neuroblastoma
• Multiple myelomas
• Sarcoma

Many of these cancers are the worst of the worst and many of the studies showing benefit are in advanced cancer (Stage III and Stage IV). The IV use of Vitamin C has even been shown to be beneficial in smoldering myeloma, the pre-cancerous state of multiple myeloma.

IV Vitamin C is not created equally for all cancers and is definitely not a one-size-fits-all approach. The patient size, tumor burden (amount of cancer present), metastasis or spread of the cancer, the type of cancer, the aggressiveness of the cancer, and whether the cancer is the primary presenting tumor or is recurrent all play a role in determining the dose and the frequency of the Vitamin C. In addition, levels should be monitored to ensure that optimal Vitamin C levels are obtained and maintained for each individual. These are some of the many reasons that IV Vitamin C therapy must be continuously monitored by someone knowledgeable in the use of IV Vitamin C therapy in the fight against cancer. The one-size-fits-all approach never works, and the use of IV Vitamin C in the treatment of cancer is no different.

Cancer is a metabolic disease

Cancer is a metabolic disease. Cancer is rarely a genetic disease. What genetic changes that exist in cancer are likely the result of the metabolic dysfunction. Dr. Lodi does not like the word disease, so let's look at that word and see why. “Disease” is an early 14th-century word that was more descriptive than diagnostic. According to the Etymology dictionary, the original meaning of the word disease meant discomfort, inconvenient, distress. The actual two root words are “dis” (without) and “aise” (ease) which gives the actual root meaning of disease as “without ease.” Interestingly, in the late 15th century the meaning of the word disease evolved to mean “to make ill.” Since traditional medicine treatments are the third leading cause of death, how can medicine not be called a means to make ill, a means to create dis aise, a disease itself.

The scientific literature really leaves little evidence for any other conclusion that cancer is anything but the result of metabolic distress. In fact, cancer is the body’s attempt to adapt, though this is a poor attempt, to the presence of a low oxygen environment, oxidative stress, and poor energy production. In the short-term, this adaptation pays dividends for survival, but in the long-term, this adaptation leads to the survival of very dysfunctional cells and what we know as cancer. The genetic defects often found in cancer are more often the result of massive metabolic dysfunction, than a foundational genetic defect. In many ways, genetic defects are the effect of rather than the cause.

I have had the pleasure of speaking at the same conference as Dr. Thomas N. Seyfried, author of Cancer is a Metabolic Disease. Dr. Seyfried is extremely well published on the mechanisms of the dysfunctional metabolism of cancer. His 2015 article Cancer as a mitochondrial metabolic disease, published in the Journal Frontiers In Cell and Developmental Biology, is a heavy, but very good read on the metabolic mechanisms behind cancer. In addition, Dr. Dominic P. D’Agostino at the University of South Florida spoke at the same conference on the use of the ketogenic diet in the management of metastatic cancer. Now, I have the opportunity to work with my good friend, Dr. Lodi, a pioneer in integrative oncology. These and other pillars in the cancer research community have helped to decipher the mechanisms behind the actions of IV Vitamin C in cancer and apply them to clinical practice. The combination of the knowledge of cancer metabolism and the mechanism and use of IV Vitamin C in cancer metabolism is a targeted, lethal combination in the fight against cancer.

To describe the mechanism of action of IV Vitamin C in cancer, I need to get a little technical so bear with me. Put on your thinking caps. Humans are one of several species that have lost the ability to make Vitamin C, hence what Vitamin C we have in our body comes through our diet and/or supplementation alone.  In addition, the human body has very limited capacity to store Vitamin C. This lack of productive capacity and lack of storage leaves most people with cancer with massive Vitamin C deficiency in what I call metabolic scurvy. One of the benefits of Vitamin C in the battle against cancer is that Vitamin C looks just like glucose.

Vitamin C is actually made from glucose by the enzyme gulonolactone oxidase. Humans lack this enzyme, which requires us to get continuous Vitamin C through our diet. As concerning as this enzymatic deficiency can be, this deficiency provides a silver lining in the fight against cancer. Cancer thrives in the typical glucose-rich environment of the western American diet. The elimination of simple sugars, excessive carbohydrates, and high process foods through the diet will starve the cancer of its primary fuel source — glucose. In the low glucose state induced by targeted nutrition plans, Vitamin C is readily taken up by the energy-starved cancer cells via the receptors SVCT1 and SVCT2 because of Vitamin C’s resemblance to glucose. In this case, Vitamin C is a stealthy metabolic time bomb for cancer cells. This is why nutrition is as much a part of treatment at an Oasis of Healing as the IV therapies are.

Is Vitamin C an antioxidant or a pro-oxidant?

Vitamin C, especially at the higher dosages, only obtainable through IV Vitamin C delivery, has been shown to be a potent pro-oxidant (not antioxidant) in cancer cells. It is this pro-oxidant activity of Vitamin C in cancer cells that generate high levels of Reactive Oxygen Species (ROS), such as H2O2, OH−, ·O2−, required to kill cancer cells. The key factor that separates cancer cells from healthy cells is that cancer cells lack certain enzymes, such as catalase and SOD, to handle these high ROS levels. Healthy cells retain appropriate catalase and SOD activity and are thus perfectly capable of handling the high ROS, hence Vitamin C functions as an anti-oxidant in healthy cells but as a pro-oxidant in cancer cells.

This high ROS presence in cancer then interacts with the high levels of Iron present in cancer cells and depletes the glutathione pool in the cancer cells. This leads to an intra-cellular oxidative stress death spiral within the cancer cells which triggers cell death (apoptosis) in the absence of the enzymes catalase and SOD. In addition, Vitamin C also behaves as an inhibitor of glycolysis. Glycolysis is a key pathway in the cell cycle of energy production and the primary mechanism of energy production in cancer cells. Vitamin C targets and blocks the activity of Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a key enzyme in glycolysis. This blockade of the GAPDH enzyme shuts down the cancer cells' favorite way to make energy. These functions make Vitamin C a potent anti-cancer therapy that leaves healthy cells unharmed. What a great combination and a novel concept!

Cancer Stem cells

Functional or integrative medicine is the new movement in medicine that seeks to identify the root cause(s) of dis aise for each individual. This movement is also a return to the roots of what a physician or doctor is — Docēre rāphè. Words have meaning and the historical meaning of the words provide perspective for a purpose. A purpose without a historical perspective is ripe for disaster. Rāphè is the Hebrew root word for physician which can be translated healer or “to heal.” Docēre is the Latin root word for the doctor which can be translated teacher or “to teach.” What is the historical perspective of a doctor? Of a physician? From a historical root perspective, a physician/doctor is one that teaches the body how to heal.

How is medicine doing in this historic mission to teach the body how to heal? As you might guess, not very good. Let the evidence speak for itself. According to data from the American Cancer Society, from 2013 to 2017, the number of deaths from cancer per year has doubled compared to new cases of cancer diagnosed over the same time frame. Despite all the new technologically advanced drugs and therapies that hit the market between 2013-2017, the diagnosis of cancer in 2017 was more terminal than a cancer diagnosis in 2013. That is an eye-opener and an indictment of the failure of physicians to hold to their historical calling—healers.

In the effort to find the root cause(s) of cancer to curb the disproportionate deaths from cancer to a diagnosis of cancer, Cancer Stem Cells (CSCs) are the new frontier in cancer research and cancer therapy. Cancer Stem Cells are the ultimate back-up for cancer.  As the back-up, CSCs are thought to be the “root cause” of:

• chemotherapy resistance
• radiation therapy resistance
• treatment failure
• tumor recurrence
• metastasis

For those affected by cancer, Cancer Stem Cells may be the difference between winning and losing. Make no mistake about it, we are all in this fight to win!

What is a cancer stem cell exactly?

In general terms, stem cells are a class of undifferentiated cells that are capable, when signaled, to differentiate or change into specialized cell types. A lot of medical jargon I know; but specifically, in the case of cancer, cancer stem cells can be used as the ultimate back-up to reproduce the original cancer cells in all of its glory of metabolic dysfunction. It is the back-up of the worst metabolic kind of dysfunction in cancer instead of the optimal metabolic function of healing cells. Back-ups are often a good and required task for protection, but in this case, we would rather do without these back-ups. These cancer stem cell back-ups, if not destroyed, will lead to treatment failure and cancer recurrence. When cancer does recur from these cancer stem cells, it is more aggressive and progressive than the original cancer presentation. Cancer stem cells are a cancers secret weapon. It is the sequel that delivers in a very bad way.

Vitamin C and cancer stem cells

What does CSC’s have to do with Vitamin C? A recent study published in the journal OncoTarget helps to identify the connection. In this study, Vitamin C was found to induce oxidative stress and inhibit glycolysis (cell energy production using glucose) via the inhibition of GAPDH in cancer cells. This may not sound like anything new or exciting, as I highlighted this mechanism earlier, but cancer, metabolically speaking, has backed itself into a metabolic corner because of its metabolic inflexibility. Most view cancer as metabolically advantaged over healthy cells, but the exact opposite is true.

Healthy cells retain the metabolic flexibility to switch from glucose to protein, or even better fats, as the primary source of energy production as dictated by the environment. Cancer cells lack this metabolic flexibility, thus limiting a cancer cells ability to adapt to changing nutrient sources. This metabolic flexibility gives healthy cells the survival advantage over cancer cells if targeted therapy is employed to target cancer’s inflexibility and it’s sole reliance on glucose as a primary source of energy production. In the study, Vitamin C (at doses that can only be obtained through IV delivery) was found to kill CSCs. Vitamin C was compared to the experimental drug 2-DG and was found to be 10 times more potent than the experimental drug (2-DG) in killing CSCs. Remember that CSCs are the ultimate backup copy to provide regrowth of the cancer cells if needed. Kill the back-up, you forever kill the potential for recurrence. Other inhibitors of the CSC energy pathways found in this study were also Silibinin, an active component of milk thistle, and caffeine acid phenyl ester (CAPE) which comes from honeybee propolis.

Want more evidence?

A more recent study published in the journal Precision Oncology found that Vitamin C kills CSCs in the very aggressive Hepatocellular (liver) cancer. The reason? Cancer stem cells more readily absorbed Vitamin C because of its high uptake of Vitamin C compared to normal cells. This high uptake of Vitamin C occurred due to the high expression of the SVTC2 receptors (discussed above) on the CSCs compared to healthy cells or even cancer cells in general. It is one thing to have high plasma Vitamin C levels in the presence of high SVTC2 receptors, but starve the CSC’s of its primary energy source, glucose, and the perfect high demand situation is created. Couple this high demand with the high presence of Vitamin C in the plasma, which looks just like glucose, and the set up is in place for the perfect stealth delivery of Vitamin C. It is the perfect wolf in sheep’s clothing, but this time, in a good way.

A third study, published in the journal OncoTarget in 2017 found that IV Vitamin C was able to kill CSCs in those cancers that were found to be resistance to the antibiotic doxycycline. This well known and commonly prescribed antibiotic has been shown to be an effective therapy against CSCs in breast, ovarian, prostate, lung, pancreatic, melanoma, and glioblastoma cancers. Interestingly, doxycycline increases the sensitivity of CSCs to radiation and chemotherapy. Some cancers, however, can escape and become resistant to these effects of doxycycline. The use of IV Vitamin C in these doxycycline resistant cancers has been shown to be highly effective in killing CSCs.

These studies conclude that Vitamin C can be used to target cancer cells in the primary tumor, cancer cells in metastasis and the ultimate back-up — cancer stem cells (CSCs). In addition, Vitamin C also targets the cancer stem Cell’s energy pathways in the mitochondria as glycolytic inhibitors. The authors of the study published in the journal OncoTarget stated:

“Vitamin C may prove to be [a] promising agent for new clinical trials, aimed at testing its ability to reduce CSC activity in cancer patients, as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression, and metastasis.” 

I agree with the entirety of the statement, but ‘may prove’? How much evidence is needed? How much time is required? Vitamin C has been studied for its anti-cancer properties since its first proposed benefit in 1954! “Time reveals all truth”. Evidence and time have proven the truth of benefit of Vitamin C in the treatment of cancer.

Because of the presence of Cancer Stem Cells, the defeat of the primary cancer tumor is just the beginning of the battle against cancer. The battle must continue with lifestyle interventions to attack CSCs in the short-term and long-term to target a life-long, disease-free survival instead of just 5 years of disease-free survival. Disease-free survival is a traditional medicine term defined as 5 years without evidence of disease. What about 5 years and 1 day? What then?

A plan of attack that includes CSCs could help redefine the disease-free survival to 10, 15, 20 years and even beyond disease. It may even eliminate the use of the word disease as the focus of physicians in medicine, restore it to its original descriptive dis aise and restore physicians to their historical purpose — healing. If you don’t shoot for the stars, you will never reach the stars and beyond.

Learn more from Dr. Goodyear with this seven-part series at An Oasis of Healing

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